The Glykys Lab focuses on understanding how the inhibitory system works at the cellular level. Clinically, we are interested in how the dysfunction of the inhibitory system leads to seizures and the relationship between neuronal edema, seizures and altered chloride homeostasis. The long-term goal of our research is to enhance the inhibitory system to better treat seizures, especially neonatal seizures. Our areas of research include: studying changes in neuronal chloride concentration and cellular volume during pathological conditions, neonatal seizures, epilepsy, and GABA(A) receptor physiology. We approach these scientific questions using electrophysiology and two-photon imaging.